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KMID : 1161420150180060631
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Journal of Medicinal Food
2015 Volume.18 No. 6 p.631 ~ p.641
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The n-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an In Vivo Model of Amyloid-β-Induced Alzheimer's Disease
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Choi Ji-Yeon
Lee Jeong-Min
Lee Dong-Gu
Cho Sung-Hun
Yoon Young-Ho
Cho Eun-Ju
Lee Sang-Hyun
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Abstract
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This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonAβ-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD.
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KEYWORD
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Alzheimer's disease, amyloid β, memory, oxidative stress, rutin, tartary buckwheat
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